Realistically what I think is going to happen is that almost no significant legislation of any kind will pass until 2017, by which point the GOP will [likely] control both the White House and the Senate and immediately eliminate the filibuster via the “nuclear” approach [meaning 50 Senators vote in favor of an opinion on the part of the President of the Senate that the super-majority is unconstitutional; thus the filibuster ceases to be]. Republicans, to their credit, tend to prioritize their vision of the national interests over issues of process and ego. Democrats, by contrast, seem to have mostly gotten into politics in order to bolster their own sense of self-righteousness and aren’t especially concerned with whether or not their conduct in office is efficacious.

Matt Yglesias, positively bubbling over with optimism for the country. If the filibuster goes in my lifetime, I think this is exactly how it will transpire, though: as the first action of a Republican controlled Senate serving a Republican President.
Yglesias is also 100% right that the credible threat of filibuster reform is more potent and much more likely to end in real reform than the actuality of that process (meaning: pushing a bill to end it with everyone knowing 67 votes aren’t out there). Democrats can never get these concepts through their heads, though. So forget about it.