Matt Yglesias asks:

There’s no mystery as to why the National Republican Campaign Committee hates Nancy Pelosi, but their dislike for San Francisco is a bit puzzling.

Almost directly, and seemingly without realizing it, Matt Yglesias also provides the answer:

[San Francisco is] an enormous economic success story. The San Francisco metropolitan area has the fourth-highest median household income in the country, with its Bay Area partner San Jose coming in at number three. Metro San Francisco is in a tie for having the third-highest-pay for low-wage workers, its fourth in median wages, and third in 90th percentile wages.

GOP orthodoxy requires “government” of any kind to be an abject and self-evident failure. Few citizens of the US would dispute the sense that San Francisco is the liberal bastion of the United States. Therefore it must be an urban hellhole and not be visited by any kind of success. Where success exists, it must be ignored. Similarly, old Taxachusetts must be forever suffering under the yoke of ludicrously high taxes (and one must never acknowledge the reality: that MA’s effective tax rates and collective tax burden generally trend lower than those of old Live Free or Die itself, that glibertarian heaven called New Hampshire).

Much like the Post Office and many other examples, any functioning example of government, large or small, must be (at a minimum) denigrated. If possible, it must also be actively undermined such that it may then be pointed to as an example of the impossibility of government intervention, large or small. All evidence to the contrary must be marginalized. And that is why the GOP “hates” San Francisco and largely assumes it to be barely survivable smoking ruin.